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目的 探讨胃复安控制抽动秽语综合征（Tourette Syndrome,TS）抽动及改善认知功能的有效性、安全性。方法 50例TS患者随机分入胃复安组或氟哌啶醇组,两组治疗前后的结果经YGTSS量表、Asberg副反应量表、韦氏智力检测进行评估。结果 胃复安、氟哌啶醇组TS的抽动程度YGTSS量表分治疗后均明显降低,组间比较胃复安组疗效更优。临床疗效的有效率均为92％。韦氏智力检测显示:治疗后的智商均有显著增加,而记忆商仅胃复安组显著增加。副反应Asberg量表分胃复安组低于氟哌啶醇组。结论胃复安能有效控制TS抽动,改善认知功能,副反应轻微,特别是无锥体外系副反应。
Objective To investigate the efficacy and safety of metoclopram in controlling twitch and improving cognitive function in Tourette Syndrome (TS). Methods Fifty patients with TS were randomly divided into metformin group and haloperidol group. The results of both groups before and after treatment were evaluated by YGTSS scale, Asberg side-response scale and Webster’s Intelligence Test. The results of metoclopramide group haloperidol TS twitch YGTSS scale points were significantly lower after treatment, the comparison between the two groups of metformin better efficacy. The clinical efficacy of the effective rate was 92%. Wechsler IQ test showed: after treatment, IQ increased significantly, while memory only metoclopramide group increased significantly. Side effects of Asberg scale sub-metoclopramide group than the haloperidol group. Conclusion Wei-Fu-An can effectively control the TS twitch, improve cognitive function, minor side effects, in particular, no extrapyramidal side effects.