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应用琼脂铺层技术检查了健康者咽部正常菌群对脑膜炎余瑟氏菌(Nm)生长的抑制作用。有些健康者咽部正常菌群对 A 群、B 群和 C 群 Nm 的生长均有抑制作用,而且这种抑菌作用较稳定.1989年冬～1990年春选择流脑发病高的江西宁都县青塘乡和该县未发病的东山坝乡与北京昌平县百善乡作为未发病地区的对照.在流脑发病率高的青塘乡只有8.5%的健康者咽部正常菌群具有抑菌作用;在东山坝乡和百善乡中分别有30%与50%的健康者咽部正常菌群可以抑制 A 群 Nm 生长。这种抑菌作用随年龄增长而增强。初步调查结果表明,健康者咽部正常菌群对 Nm 原发感染似乎有一定的影响。我们对调查中所收集的对 Nm 具有抑菌作用的细菌按 Bergey 氏手册进行了鉴定,现已确定它们是血液链球菌、缓症链球菌、米勒氏链球菌和唾液链球菌四种。
The inhibition of the growth of N. meningitidis (Nm) by normal pharyngeal flora in healthy subjects was examined using agar laminate technique. Some healthy normal pharyngeal flora of the A group, B group and C group Nm growth inhibition, and this antibacterial effect is more stable .1989 winter ~ 1990 spring to choose high incidence of meningitis in Jiangxi Ningdu County Green Tangshan Township and the county uninfarmed Dongshanba Township and Beijing Changping County Baishan Township as a non-endemic areas in the control of the high incidence of meningitis in Qingtang Township, only 8.5% of healthy normal pharyngeal flora has antibacterial effect ; In the Dongshanba Township and Baishan Township, 30% and 50% of healthy normal pharyngeal flora can inhibit A group Nm growth. This antibacterial effect increases with age. Preliminary findings show that healthy normal pharyngeal flora seems to have a certain impact on the primary infection of Nm. We identified Bernsky’s manuals on bacteria that have an antibacterial effect on Nm collected during the survey. We have determined that they are four of Streptococcus aureus, Streptococcus pyogenes, Streptococcus Miller and Streptococcus salivarius.