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为了评价培哚普利与钠催离联合治疗对预防中风再发的作用 ,选择了 80名有中风或一过性脑缺血发作史患者 ,随机分为两组 ,分别用培哚普利 (4mg/d)与钠催离 (2 .5mg/d)联合治疗或相应安慰剂治疗 4年 ,观察治疗前后血压、血钾、血肌酐、MMSE计分及中风、心血管事件和残疾的发生情况。研究结果发现 :两组药物联合治疗降压作用显著且平稳 ,血肌酐有下降趋势 ,血钾无显著变化 ,MMSE计分增加 ;与安慰剂对照组相比 ,治疗组发生中风 (10 %比 30 % ) ,总心血管事件 (10 %比 30 % ) ,认知功能障碍 (5 %比 2 2 .5 % )和残废 (2 .5 %比 2 5 % )的危险性降低 ,P均 <0 .0 5。本文结果提示 :培哚普利与钠催离联合治疗能降低再中风危险 ,减少心血管事件发生 ,改善认知功能和生活质量 ,且副作用少 ,耐受性好。
To evaluate the role of perindopril combined with sodium in the prevention of stroke recurrence, 80 patients with a history of stroke or transient ischemic attack were enrolled and randomly assigned to receive either perindopril 4mg / d) combined with sodium (2.5mg / d) or placebo for 4 years. The changes of blood pressure, serum potassium, serum creatinine, MMSE, stroke, cardiovascular events and disability were observed before and after treatment . The results showed that: the two groups of drug combination treatment of antihypertensive effect was significant and stable, serum creatinine decreased, no significant change in serum potassium, MMSE score increased; compared with the placebo control group, the treatment group had a stroke (10% to 30 %), Total cardiovascular events (10% vs 30%), cognitive impairment (5% vs 22.5%) and disability (2.5% vs 25% .0 5. The results suggest that: Perindopril and sodium combined treatment can reduce the risk of stroke, reduce cardiovascular events, improve cognitive function and quality of life, with fewer side effects and good tolerance.