【摘 要】
：
There is currently a pressing need for alternative the-rapies to liver transplantation. The number of patients waiting for a liver transplant is substantially h
【机 构】
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Department of Surgery, Keck School of Medicine, University of Southern California,
【出 处】
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World Journal of Gastroenterology
论文部分内容阅读
There is currently a pressing need for alternative the-rapies to liver transplantation. The number of patients waiting for a liver transplant is substantially higher than the number of transplantable donor livers, resulting in a long waiting time and a high waiting list mortality. An extracorporeal liver support system is one possible approach to overcome this problem. However, the ideal cell source for developing bioartificial liver(BAL) support systems has yet to be determined. Recent advancements in stem cell technology allow researchers to generate highly functional hepatocyte-like cells from human pluripotent stem cells(h PSCs). In this mini-review, we summarize previous clinical trials with different BAL systems, and discuss advantages of and potential obstacles to utilizing h PSC-derived hepatic cells in clinical-scale BAL systems.
There is currently a pressing need for alternative the-rapies to liver transplantation. The number of patients waiting for a liver transplant is substantially higher than the number of transplantable donor livers, resulting in a long waiting time and a high waiting list mortality. An extracorporeal However, the ideal cell source for developing bioartificial liver (BAL) support systems has yet to be determined. Recent advances in stem cell technology allow researchers to generate highly functional hepatocyte-like cells from In this mini-review, we summarize previous clinical trials with different BAL systems, and discuss advantages and potential obstacles to utilizing h PSC-derived hepatic cells in clinical-scale BAL systems.
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