It is usually reported that reaction between carbonyl and P2S5 produce thiono group compound. The Products from carbonyl after ammonolysis and hydrazinolysis have the very import applied value in the synthesize of heterocyclic compound. Sulfuration reation if a nucleophilic attack,SPS2 anionsid obtained from P2S5 in the organic sovent, rather easier than thereationsof scheerens reagent. The reation mechanism is as follows:The reation speed has something todo with the electronegative of R1R2 can be aliphatic group or aromatic group. The reaction can take place in the polar solvent or non-polar solent.But it is seldom reported that cyclic amide can be sulfured. In 1964, G.A, Archer et made the 7-chloro-1,3-dihyhro-5-phenyl 2H-1,4-ebnzodiazepin-2-thioue and in the reation of pyridine solent with 7-chloro-1,3-dilydro-5-phenyl-2H-1,4-benzodiazepin-2-one and P2S5. And the yield rate reached 40%. This reaction is very important in the pharmaceutical compound, but has quite low yield rate and high cost with present method. And the application is restricted duo to the pyridine,but it is a feasible way indeed. So we undertook further the deep studyof this, made P2S5 catalytic sulfurization in the proper solvent. And the yield rate of the reation has raised a lot. The quality of this product has been affirmed by UV. IR. 1HMNR.MS chart. This method successfully has been applied for the pharmaceutical compound, such as, Estazolam, Trithlozine Alprazolam, Triazolam Clozapine. This has been applied for manufacturing with obvious economic and social benefit.