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应用支气管肺泡灌洗技术（ＢＡＬ）采集１２例慢性支气管炎缓解期病人和１２例正常人的肺泡巨噬细胞（ＡＭ），进行体外培养。结果慢支组ＡＭ培养后存活率明显下降，所获ＡＭ总数两组间无显著差异性，但慢支组ＢＡＬ回收液体的细胞分类中ＡＭ比例下降，中性粒细胞比例相对增高；慢支组ＡＭ培养前以中、大ＡＭ为主，其培养后及正常对照组培养前、后均以中、小ＡＭ为主、两组间有显著差异性（Ｐ＜０．０５）。表明慢支缓解期病人ＡＭ更易活化，活化的ＡＭ释放一系列炎性介质，对慢支发生发展有重要影响。
Alveolar macrophages (AM) from 12 patients with chronic bronchitis and 12 normal controls were collected by bronchoalveolar lavage (BAL) technique and cultured in vitro. Results The survival rate of chronic bronchitis group was significantly decreased after AM training. There was no significant difference between the two groups in the total number of AM. However, the percentage of AM in the cell classification of bronchoalveolar lavage fluid was decreased and the proportion of neutrophils was increased in chronic bronchitis group. AM was mainly cultured in medium and large AM before and after culture, and both AM and AM before and after culture were significantly different between the two groups (P <0.05). It shows that AM is easier to activate in patients with chronic bronchitis and active AM releases a series of inflammatory mediators, which have a significant impact on the development of chronic bronchitis.