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以大肠癌裸鼠移植瘤为动物模型，观察了分叉双歧杆菌的完整肽聚糖体内对大肠癌生长的抑制作用，并从细胞增殖活性方面探讨了它的抑瘤机制。结果表明完整肽聚糖注射组大肠癌移植瘤的生长速度、平均瘤重以及增殖细胞核抗原（ＰＣＮＡ） 阳性细胞密度均明显低于肿瘤对照组（Ｐ＜ ０．０１） 。提示分叉双歧杆菌的完整肽聚糖体内能明显抑制大肠癌的生长，其抑瘤机制之一是降低肿瘤细胞的增殖活性。
A colorectal cancer xenograft in nude mice was used as an animal model to observe the inhibitory effect of the intact peptidoglycan from bifidobacterium bifidum on the growth of colorectal carcinoma, and its antitumor mechanism was discussed in terms of cell proliferation activity. The results showed that the growth rate, mean tumor weight, and proliferating cell nuclear antigen (PCNA) positive cell density of the transplanted colon cancer in the intact peptidoglycan group were significantly lower than those in the tumor control group (P<0.01). The complete peptidoglycan of bifidobacterium bifidum in vivo can obviously inhibit the growth of colorectal cancer. One of its anti-tumor mechanisms is to reduce the proliferation activity of tumor cells.