目的探讨朗格汉斯细胞组织细胞增生症(LCH)的临床诊断与治疗。方法回顾性分析近5年诊断的8例LCH的临床资料,并结合复习相关文献。结果 8例患者首发症状多变,均经组织病理活检确诊,其中6例予以化疗,2例未行治疗。结论 LCH是一组病因不明的异质性疾病,其临床表现不典型,确诊主要依赖组织病理学及免疫组化检查,个体化治疗很重要,其确切疗效仍待进一步评估。 Objective To investigate the clinical diagnosis and treatment of Langerhans cell histiocytosis (LCH). Methods The clinical data of 8 cases of LCH diagnosed in recent 5 years were retrospectively analyzed, and the related literatures were reviewed. Results The initial symptoms of 8 patients were varied. All of them were confirmed by histopathological biopsy. Among them, 6 patients received chemotherapy and 2 patients did not receive treatment. Conclusions LCH is a group of heterogeneous diseases with unknown etiology. The clinical manifestations are not typical. The diagnosis depends mainly on histopathology and immunohistochemistry. Individualized treatment is very important. The exact effect remains to be evaluated.