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前列腺发生于泌尿生殖窦上皮 ,是雄激素依赖的器官。雄激素及其受体在前列腺的发生、生长、分化和功能的维持上起着重要的作用。雄激素 (Ｔ)主要由睾丸间质细胞 (ＬｅｙｄｉｇＣｅｌｌ)合成、分泌 ,通过 5α 还原酶 (主要是Ⅱ型 )的作用能转化成更具生物活性的脱氢睾酮 (ＤＨＴ
The prostate gland occurs in the urogenital sinusoidal epithelium and is an androgen-dependent organ. Androgens and their receptors play an important role in the occurrence, growth, differentiation and maintenance of function of the prostate. Androgens (T) are mainly synthesized and secreted by Leydig cells and can be converted into more biologically active dehydrotestosterone (DHT) by the action of 5α reductase (mainly type II).