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猕猴吸入10%的氧时,肺动脉压明显升高,肺血管阻力显著增加。缺氧三分钟即出现最大反应,其肺血管阻力变化率达39.6%。缺氧持续十分钟,HPV未见明显减弱。脂氧合酶抑制剂——乙胺嗪明显抑制猕猴的HPV,但给药后六十分钟,HPV恢复到给药前的水平。环氧合酶抑制剂——消炎痛则明显增强猕猴的HPV,最大肺血管阻力变化率可达57%。这些结果提示:花生四烯酸脂氧合酶代谢产物——白三烯在猕猴的HPV中可能起介导作用,而前列腺素则可能调整HPV,这种调整作用与某些扩血管性前列腺素的作用有关。
Rhesus macaque inhalation of 10% oxygen, pulmonary hypertension was significantly increased, pulmonary vascular resistance increased significantly. Hypoxia three minutes that the maximum response, the rate of change of pulmonary vascular resistance rate of 39.6%. Hypoxia lasted ten minutes, HPV did not significantly reduced. Lipoxygenase inhibitor - diethylcarbamazine significantly inhibits cynomolgus monkeys’ HPV, but sixty minutes after dosing, HPV returns to pre-dose levels. The cyclooxygenase inhibitor, indomethacin, significantly increased macaque HPV, with a maximal change in pulmonary vascular resistance of 57%. These results suggest that arachidonic acid lipoxygenase metabolites, leukotrienes, may play a mediating role in the rhesus monkey HPV while prostaglandins may modulate HPV, a regulative effect that is associated with certain vasodilator prostaglandins The role of.