目的 :探讨血清阳性 (SPMG)和阴性重症肌无力 (SNMG)被动转移动物模型 (P EAMG)的异同。方法 :用ELISA法将重症肌无力 (MG)患者分为SNMG和SPMG两组 ,然后分别用两组患者血清制作P EAMG ,观察两组小鼠的临床表现、电生理及神经肌接头(NMJ)的改变。结果 :SPMG和SNMG组小鼠均表现出明显的肌无力症状 ,低频重复电刺激出现明显衰减反应 ,但SNMG组小鼠肌无力症状较SPMG组明显为轻 ,SPMG和SNMG组小鼠NMJ处棕黄色沉积物明显减少、变细短。结论 :SNMG和SPMG均是自身抗体介导的自身免疫性疾病 ,但两者不完全相同 Objective: To investigate the similarities and differences between the serum positive (SPMG) and negative myasthenia gravis (SNMG) passive metastatic animal models (P EAMG). Methods: Patients with myasthenia gravis (MG) were divided into SNMG group and SPMG group by ELISA. Then, P EAMG was produced by serum of two groups. The clinical manifestations, electrophysiology and neuromuscular junction (NMJ) Change. Results: The mice in both SPMG and SNMG groups showed obvious symptoms of myasthenia gravis. There was a significant attenuated response in low-frequency repetitive electrical stimulation. However, the mice with SNMG had less muscle weakness than those in SPMG group. Yellow sediments significantly reduced, thinner and shorter. Conclusion: Both SNMG and SPMG are autoantibody-mediated autoimmune diseases, but the two are not exactly the same