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肿瘤细胞多药耐药性是临床化疗失败的主要原因之一。化学药逆转剂因其毒副作用较大、靶点单一,应用受到限制,而中药具有高效、低毒、多靶点的特性,是近年来的研究热点。通过对近年来能够逆转肿瘤细胞多药耐药的中药单体成分、中药提取物以及中药复方的综述,探讨中药逆转肿瘤细胞多药耐药的研究进展及肿瘤细胞多药耐药逆转剂的开发前景。
Multidrug resistance of tumor cells is one of the main reasons for the failure of clinical chemotherapy. Because of its toxic side effects, single target and limited application, traditional Chinese medicine reversal agent has the characteristics of high efficiency, low toxicity and multiple targets. It is a hot research topic in recent years. In recent years, we can reverse the reversal of multi-drug resistance of traditional Chinese medicine monomer components of Chinese herbal medicine, traditional Chinese medicine extract and traditional Chinese medicine compound review of traditional Chinese medicine to reverse the progress of multi-drug resistance of tumor cells and development of multidrug resistance tumor drug agents prospect.