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IL-8是一种细胞因子,属于趋化因子超家族中的一员,是体内炎性反应应答的主要介质之一。近年研究发现,该因子的生理和病理作用极为广泛,能促进炎性反应进程、刺激血管形成、促有丝分裂、调节宿主免疫功能等,与多种炎性反应性疾病的发生发展,肿瘤的发生、生长转移及多种免疫性疾病密切相关。现就该因子的组织来源、基因定位及结构、受体结构、转录及调控、生物学功能等一般特性,及其与炎性反应、肿瘤的研究进展作一综述。
IL-8, a cytokine that belongs to a member of the chemokine superfamily, is one of the major mediators of the inflammatory response in the body. In recent years, the study found that the factors of the physiological and pathological role is extremely broad, can promote the inflammatory response process, stimulate angiogenesis, mitosis, regulate host immune function, with a variety of inflammatory response diseases, tumor development, Growth and metastasis and a variety of immune diseases are closely related. Now the factors of the organization, gene location and structure, receptor structure, transcription and regulation, biological functions and other general characteristics, and its progress with inflammatory response, cancer are reviewed.