论文部分内容阅读
作者分析了1966～1970年五年期间瑞典药物不良反应委员会所收到的药物引起的再生障碍性贫血(AA)、溶血性贫血(HA)、血小板减少症(TP)和粒细胞缺乏症(AG)病例报告,并与瑞典中部Uppsala地区所收集的各种原因引起的相同的血细胞减少症病例作比较。结果:药物引起的血液病的发病率在儿童和青年期都很低,但随年龄而增加。药物引起的HA占全部HA的4％,药物引起的AA和TP均占全部AA和TP的5％。AA随年龄的增加而减少,而TP则随年龄的增加而增加。药物引起的AG占全部AG病例的19％,随年龄的增加而急剧上升。
The authors analyzed drug-induced aplastic anemia (AA), hemolytic anemia (HA), thrombocytopenia (TP) and agranulocytosis (AG) received by the Swedish Adverse Drug Reactions Committee during the five-year period from 1966 to 1970 ) Case report and compared with the same cases of cytopenia caused by various causes collected in the Uppsala area of central Sweden. Results: The incidence of drug-induced blood diseases was low in both children and adolescents, but increased with age. Drug-induced HA accounts for 4% of total HA, and drug-induced AA and TP account for 5% of total AA and TP, respectively. AA decreases with age, while TP increases with age. Drug-induced AG accounts for 19% of all cases of AG, with a sharp increase in age.