This paper reports a synergistic design of high-performance BCC high-entropy alloy based on the com-bined consideration of the principles of intrinsic ductility of elements,maximum atomic size difference for solid solution strengthening and the valence electron concentration criterion for ductility.The single-phase BCC HfNbTaTiV alloy thus designed exhibited a high compressive yield strength of 1350 MPa and a high compressive ductility of ＞45 ％ at the room temperature.This represents a 50 ％ increase in yield strength relative to a HfNbTaTiZr alloy.This is attributed to the maximized solid solution strengthening effect caused by lattice distortion,which is estimated to be 1094 MPa.The alloy was also able to retain 53 ％ of its yield strength and 77 ％ of its ductility at 700 ℃.These properties are superior to those of most refractory BCC high-entropy alloys reported in the literature.