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The preparation of ultra-fine particles of salbutamol sulphate(SS)was accomplished with a reactiveprecipitation pathway,in which salbutamol and sulphuric acid were used as reactants with the solvents of ethanol.The effects of sulphuric acid concentration,reaction temperature,stirring rate,and reaction time on the size of theparticle were investigated.A binary mixture composed of lactose and SS was prepared to evaluate SS.The resultsshowed that ultra-fine SS particles with controlled diameters ranging between 3μm and 0.8μm and with a narrowdistribution could be achieved.The morphology consisting of clubbed particles was successfully obtained.The pu-rity of the particles reached above 98%with UV detection.The dose of dry powder inhalation was obtained byblending the particles with recrystallized lactose,which acted as a carrier.The deposition quantity of the drug inbreathing tract was estimated using a twin impinger apparatus.Compared with the Shapuer powder(purchased inthe market),the results showed that SS particles had more quantities subsided in simulative lung.
The preparation of ultra-fine particles of salbutamol sulphate (SS) was accomplished with a reactive precipitation pathway, in which salbutamol and sulphuric acid were used as reactants with the solvents of ethanol. The effects of sulphuric acid concentration, reaction temperature, stirring rate, and reaction time on the size of the particle were investigated. A binary mixture composed of lactose and SS was prepared to evaluate SS. The resultsshowed that ultra-fine SS particles with controlled diameters ranging between 3 μm and 0.8 μm and with a narrow distribution could be achieved. morphology consisting of clubbed particles was successfully obtained. The pu-rity of the particles reached above 98% with UV detection. The dose of dry powder inhalation was obtained byblending the particles with recrystallized lactose, which acted as a carrier. the deposition quantity of the drug inbreathing tract was estimated using a twin impinger apparatus. Compared with the Shapuer powder (purchased inthe market), the results showed that SS particles had more quantities subsided in simulative lung.