在大鼠离体海马脑片标本表面灌流荷包牡丹碱(10μmol·L~(-1)),单脉冲电刺激Schaffer侧支,激活CAl区锥体细胞,给出痫样放电,作者在这种痫样放电模型上研究了加锡果宁对该痫样放电的影响,结果表明,微量推注不同浓度的加锡果宁到脑片CAl区表面,对荷包牡丹碱诱发的CAl区锥体细胞痫样放电呈剂量依赖性抑制,提示加锡果宁可对抗荷包牡丹碱的致痫作用,并讨论了可能机理。 Peri-bicuculline (10 μmol·L -1) was perfused on the surface of rat hippocampal slices, and single-pulse electrical stimulation of Schaffer collaterals activated pyramidal cells in the CA1 region, giving rise to epileptiform discharges. Epileptiform discharge model to study the effect of cortex tinnin on the epileptiform discharge, the results show that the micro-injection of different concentrations of tin and tin to the brain CAl area surface, the bicuculline induced CAl pyramidal cells Epileptiform discharges in a dose-dependent manner, suggesting that tin can be used in the fight against cingrucine induced epileptic seizures, and discussed the possible mechanism.