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目的探讨晚期非小细胞肺癌(NSCLC)应用体外射频热疗联合紫杉醇+顺铂(TP)化疗方案的近期疗效。方法回顾性分析74例晚期NSCLC患者,根据治疗方案不同分为观察组和治疗组。观察组36例,给予射频热疗联合紫杉醇和顺铂(TP方案)化疗;对照组38例,仅给予TP方案化疗。均予以4个周期疗程,比较两组的近期疗效、生活质量评分及不良反应发生率的差异。结果与对照组比较,观察组患者的症状控制率、完全缓解率和总有效率明显较高(P<0.05);且生活质量改善率也显著增高(P<0.05)。两组患者的骨髓抑制、胃肠道反应及神经毒性反应的发生率差异无统计学意义(P>0.05)。结论体外射频热疗联合TP化疗方案治疗晚期NSCLC近期疗效显著,安全性好。
Objective To investigate the short-term effect of radiofrequency ablation combined with paclitaxel plus cisplatin (TP) chemotherapy in advanced non-small cell lung cancer (NSCLC). Methods A retrospective analysis of 74 patients with advanced NSCLC patients were divided into observation group and treatment group according to the different treatment options. In the observation group, 36 cases were given radiofrequency thermotherapy combined with paclitaxel and cisplatin (TP regimen) chemotherapy; control group, 38 cases, only given TP regimen chemotherapy. All were given 4 cycles of treatment, comparing the two groups of short-term efficacy, quality of life scores and the incidence of adverse reactions. Results Compared with the control group, the symptom control rate, complete remission rate and total effective rate in observation group were significantly higher (P <0.05), and the quality of life improvement rate was also significantly higher (P <0.05). There was no significant difference in the incidence of bone marrow suppression, gastrointestinal reaction and neurotoxicity between the two groups (P> 0.05). Conclusion In vitro radiofrequency thermotherapy combined with TP chemotherapy in the treatment of advanced NSCLC has obvious curative effect and good safety.