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近些年来,越来越多的实验资料证实生长激素(GH)在免疫系统发育和功能维持中具有重要的作用。GH 的分泌与胸腺发育相平行,外源性GH 能阻止和恢复老年动物胸腺的萎缩,增加胸腺素合成。人淋巴细胞有GH 受体,也能分泌GH;其分泌的GH 生物学活性、抗原性和分子量与垂体分泌的GH 一致。GH 能增强T 杀伤细胞、NK 细胞活性,亦能活化巨噬细胞和影响多核细胞的吞噬活性。GH 对免疫系统的调节可能是通过调控淋巴组织的生长来实现的。
In recent years, more and more experimental data confirm that growth hormone (GH) plays an important role in immune system development and function maintenance. GH secretion parallel to the development of the thymus, exogenous GH can prevent and restore the thymus in elderly animal atrophy, increase thymosin synthesis. Human lymphocytes have GH receptors, but also can secrete GH; its secretion of GH biological activity, antigenicity and molecular weight and pituitary secretion of GH consistent. GH can enhance T killer cells, NK cell activity, but also activate macrophages and affect the phagocytic activity of multinucleated cells. GH regulation of the immune system may be through the regulation of lymphoid tissue growth to achieve.