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目的:观察利胆排石汤对肝胆结石患者胆汁成分的影响,并探讨其临床疗效。方法:将肝胆结石患者80例随机分为2组各40例,对照组给予内窥镜括约肌切开术(EST)取石治疗,研究组在对照组的基础上口服利胆排石汤,术后均进行常规治疗,分别检测2组治疗前后胆汁生化指标及肝功能指标,并对治疗效果进行评价。结果:总有效率研究组为80.0%,对照组为55.0%,2组比较,差异有统计学意义(P<0.01)。术后7天,2组胆汁总胆汁酸含量较术后1天升高(P<0.05),总胆固醇、直接胆红素(对照组除外)、间接胆红素、钙离子含量较术后1天降低(P<0.05,P<0.01);研究组术后7天上述指标改善与对照组比较,差异有统计学意义(P<0.05,P<0.01)。术后1月2组血清AKP、ALT、r-GT、5,-NT等指标均较术后1天改善(P<0.05,P<0.01);研究组上述指标改善与对照组比较,差异有统计学意义(P<0.05,P<0.01)。结论:排石汤配合EST术治疗肝胆结石临床疗效显著,可改善患者病理性胆汁成分,改善患者肝胆功能。
Objective: To observe the effect of Li Dan Paishi Decoction on the bile component in patients with hepatobiliary stone and to explore its clinical efficacy. Methods: 80 patients with hepatobiliary stone were randomly divided into two groups of 40 cases, the control group was given endoscopic sphincterotomy (EST) stone treatment, the study group in the control group based on oral administration of gallbladder Paishi Decoction After the conventional treatment, respectively, two groups were detected before and after treatment of biochemical indicators of bile and liver function indicators, and evaluate the therapeutic effect. Results: The total effective rate was 80.0% in the study group and 55.0% in the control group. There was significant difference between the two groups (P <0.01). After 7 days, the content of total bile acid in bile in group 2 was higher than that in one day after operation (P <0.05), the content of total cholesterol and direct bilirubin (except control group), indirect bilirubin, Day (P <0.05, P <0.01). The improvement of the above indexes in the study group at 7 days after operation was statistically significant compared with the control group (P <0.05, P <0.01). The serum AKP, ALT, r-GT, 5, -NT and other indexes in the first 2 months after operation were all improved compared with the 1st day after operation (P <0.05, P <0.01). The improvement of the above indexes in the study group compared with the control group Statistical significance (P <0.05, P <0.01). Conclusion: Paishi Decoction combined with EST is effective in treating hepatobiliary calculi, which can improve pathological bile composition and improve hepatobiliary function in patients.