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IN ORDER TO OBSERVE IT BLOCKERS OF SODIUM CHANNEL OBSESSES THE NEUROPROTECTIVE EFFECT ON HIPPOCAMPAL CA 1 PYRAMIDAL CELL UNDER THE CONDITION OF TRANSIENT BRAIN ISCHEMIA, THE PRESENT EXPERIMENT USED 24 MALE WISTAR RATS AGED 9 MONTHS AND DIVIDED THEM INTO FOUR GROUPS. LIDOCAINE AND/OR FUROSEMIDE WERE INJECTED INTROCEREBROVENTICULARLLY (I.C.V). STAINED WITH H E AND ACCOUNTED THE CA 1 PYRAMIDAL CELL NUMBERS BY COMPUTER IN EACH GROUP SUGGESTED FOLLOWING FINDINGS: ALTHOUGH 5 μL OF 2%LIDOCAINE WAS INJECTED I.C...“,”In order to observe it blockers of sodium channel obsesses the neuroprotective effect on hippocampal CA 1 pyramidal cell under the condition of transient brain ischemia, the present experiment used 24 male Wistar rats aged 9 months and divided them into four groups. Lidocaine and/or furosemide were injected introcerebroventicularlly (I.C.V). Stained with H E and accounted the CA 1 pyramidal cell numbers by computer in each group suggested following findings: Although 5 μl of 2% lidocaine was injected I.C.V, the results indicated lidocaine didn't have any blockade to pyramidal cell injuries in hippocampal CA 1 area (P<0 05). In the group medicated with 2 5μl of both 2% lidocaine and 2% furosemide, the results showed that the combined approach had a blockade to injuries of pyramidal cells compared with control group (P<0 01). The present experiment indicates that the combined blockade of lidocaine and furosemide injected I.C.V. to Na + channel can prevent the injuries from hippocampal neurons owing to ischemia.