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目的探讨准分子激光屈光性角膜切削术（ＰＲＫ）后角膜厚度改变与ＰＲＫ疗效的关系。方法采用ＤＧＨ４０００Ａ超角膜测厚仪，随机检测 ＰＲＫ术后 １月、６月、１ａ、２ ａ患者角膜中央厚度（共 １５０例 ２８７眼），动态观察术后角膜中央厚度的改变及影响因素。结果Ａ组平均角膜切削深度７１．７７μｍ，术后角膜实际减少厚度与理论角膜切削深度相接近，术后 ２ ａ裸眼视力 １． １８ ± ０．２２，残留屈光度（０．３８±０．５３）Ｄ。 Ｃ组平均角膜切削深度 １０３．３ μｍ，术后角膜实际减少厚度与理论角膜切削深度变异大，显示角膜增厚，术后２ａ裸眼视力０．８９±０．２８，残留屈光度（－１２５±１．５１）Ｄ。Ｂ组介于Ａ组与 Ｃ组之间。结论 ＰＲＫ近视治疗屈光度在－６．００ Ｄ以下，角膜切削深度控制在 ８０ μｍ以内，术后角膜中央厚度改变小，疗效好；治疗屈光度大于－８．００ Ｄ，角膜切削深度≥１００ μｍ，则角膜中央厚度增厚明显，疗效差。
Objective To investigate the relationship between corneal thickness and PRK after excimer laser photorefractive keratectomy (PRK). Methods The central corneal thickness (total 150 cases, 287 eyes) of PRK patients at 1, 6, 1 and 2 years after PRK was detected by DGH4000A ultrasonography. The changes of central corneal thickness and the influencing factors were observed dynamically. Results The average depth of corneal ablation in group A was 71.77μm. The actual corneal thickness after corneal resection was close to the theoretical corneal ablation depth. 18 ± 0.22, residual refraction (0.38 ± 0.53) D. The average corneal cutting depth was 103.3 μm in group C, and the actual corneal thickness and the corneal cutting depth were significantly different after operation. The corneal thickening was observed. The visual acuity of uncorrected visual acuity was 0.89 ± 0.28 and residual refractive power (-125 ± 1 .51) D. Group B is between A and C groups. Conclusions PRK myopia in the treatment of refractive error -6.00 D below corneal depth of control within 80 μm, postoperative central corneal thickness change is small, good effect; treatment of refraction greater than -8.00 D corneal cutting depth of ≥ 100 μm, then Thick central corneal thickening significantly, poor efficacy.