目的:研究早期肠内营养(EEN)对休克病人内毒素和肿瘤坏死因子-α(TNF-α)的影响及对多器官功能障碍综合征(MODS)的治疗作用。方法:将146例休克后病人分为EEN组和肠外营养(TPN)组,检测两组病人营养支持治疗前和治疗后第1、3、5天血浆中内毒素和TNF-α水平变化。统计两组病人28 d的MODS患病率和病死率。结果:EEN组休克病人第5天后血浆内毒素和TNF-α明显低于TPN组(P<0.01)。两组间MODS的患病率无显著性差异。EEN组病人MODS的病死率显著低于对照组(P<0.05)。结论:EEN可显著降低休克后病人血浆内毒素和TNF-α水平,降低了MODS的病死率。 Objective: To study the effects of early enteral nutrition (EEN) on endotoxin and tumor necrosis factor-α (TNF-α) and the treatment of multiple organ dysfunction syndrome (MODS) in shock patients. Methods: The 146 post-shock patients were divided into EEN group and parenteral nutrition group (TPN). The levels of plasma endotoxin and TNF-α in the two groups before and after treatment were detected. The morbidity and mortality of MODS were calculated on the 28th day in both groups. Results: The levels of plasma endotoxin and TNF-α in the EEN group were significantly lower than those in the TPN group after 5 days (P <0.01). There was no significant difference in the prevalence of MODS between the two groups. The mortality of MODS in EEN group was significantly lower than that in control group (P <0.05). Conclusion: EEN can significantly reduce the level of plasma endotoxin and TNF-α in patients after shock and reduce the mortality of MODS.