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目的探讨单纯低T4血症对妊娠期妇女妊娠结局及胎儿的影响。方法 264例合并单纯低T4血症妊娠中晚期妇女分为治疗组170例和未治疗组94例,并以同期69例健康妊娠中晚期妇女为对照组,比较各组母婴甲状腺激素(TSH、FT4)测定情况、妊娠结局以及新生儿一般情况。结果孕中期对照组FT4高于未治疗组、治疗组,未治疗组与治疗组差异无统计学意义(P>0.05);孕晚期对照组、治疗组、未治疗组依次降低,组间差异均有统计学意义(P<0.05)。孕中期与孕晚期FT4对照组、未治疗组差异均无统计学意义(P>0.05),治疗组FT4出现升高,差异有统计学意义(P<0.05)。未治疗组妊娠期高血压疾病、妊娠期糖尿病以及胎盘早剥发生率高于对照组及治疗组,差异有统计学意义(P<0.05),对照组与治疗组比较差异无统计学意义(P>0.05)。未治疗组胎儿窘迫发生率高于其他两组,1min Apgar评分低于7分居多,对照组、治疗组胎儿窘迫、1min Apgar评分差异无统计学意义(P>0.05)。结论单纯低T4血症与妊娠期母婴并发症诸如妊娠期高血压疾病、妊娠期糖尿病、胎盘早剥以及胎儿窘迫关系密切,对单纯低T4血症进行针对性的治疗具备必要性。
Objective To investigate the effect of simple hypoglycaemia on pregnancy outcome and fetus in pregnant women. Methods Two hundred and sixty-six women with mild hypoglycemia in the second and third trimester of pregnancy were divided into treatment group (n = 170) and untreated group (n = 94). Sixty-nine healthy pregnant women in the same period were taken as control group. Thyroid hormone (TSH, FT4) determination of the situation, the outcome of pregnancy and the general situation of newborns. Results Compared with the untreated group, FT4 in the control group at the second trimester was not significantly different (P> 0.05). The control group, the treatment group and the untreated group in the third trimester of pregnancy decreased in turn, There was statistical significance (P <0.05). There was no significant difference between FT4 control group and untreated group in the third trimester and third trimester of pregnancy (P> 0.05). The FT4 level in the treatment group increased significantly (P <0.05). The incidence of gestational hypertension, gestational diabetes mellitus and placental abruption in untreated group was significantly higher than that in control group and treatment group (P <0.05), but there was no significant difference between control group and treatment group (P > 0.05). The incidence of fetal distress in the untreated group was higher than that in the other two groups, and the Apgar score was less than 7 at 1 minute. There was no significant difference in the 1 week Apgar score between the control group and the treatment group (P> 0.05). Conclusions Simple hypoglycaemia is closely related to maternal and neonatal complications such as gestational hypertension, gestational diabetes mellitus, premature placental abortion and fetal distress during pregnancy. It is necessary to treat the patients with pure hypomagnesemia.