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目的探讨苯妥英钠（PHT）对癫痫儿认知功能的影响及叶酸制剂对其认知功能障碍的改善作用。方法14名患儿采用自身前后对照，于PHT治疗3mo后加服叶酸制剂，分析PHT治疗前、治疗3mo、治疗6mo后认知功能及血清叶酸、维生素B12的变化。结果PNT治疗3mo后，患儿的记忆力、注意力、精细运动及视觉保持能力明显降低。接受叶酸制剂后患儿认知功能明显改善。血清叶酸、维生素B12与认知功能之间有显著相关性。结论PHT对癫痫患儿认知功能的影响与PHT引起患儿血清维生素B12水平降低有关。加服叶酸制剂对癫痫患儿的认知功能有显著的改善作用。
Objective To investigate the effect of phenytoin sodium (PHT) on cognitive function in children with epilepsy and the effect of folic acid preparation on cognitive impairment. Methods Fourteen children underwent self-contrast before and after treatment with PHT for 3 months. The changes of cognitive function, serum folate and vitamin B12 were analyzed before and 3 months after PHT treatment. Results 3 months after PNT treatment, children’s memory, attention, fine motor and visual retention was significantly reduced. After receiving folic acid preparations children’s cognitive function improved significantly. Serum folic acid, vitamin B12 and cognitive function have a significant correlation between. Conclusion The effect of PHT on cognitive function in children with epilepsy is related to the decrease of serum vitamin B12 level in children with PHT. Additional folic acid preparations on cognitive function in children with epilepsy have a significant improvement.