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患者20岁,女性。体重下降,间歇性腹泻伴直肠出血6个月,钡餐造影诊断为广泛小肠克隆氏病,直肠活检证实有克隆氏病的肉芽肿。用强的松龙40mg/日,因出现严重精神病而被迫停药。此后一年中,虽用抑氮磺胺嘧啶2-3g/日,克隆氏病仍在发展。体重下降、踝肿、低蛋白血症、停经。遂改用口服 Cyclosporin 16mg/kg/日及8mg/kg/日。此期间未用其他治疗。经8周治疗,患者一般状况改善,腹痛消失,大便正常,踝部浮肿消失,月经失调改善。血沉从45降至28mm/hr,持续升高
Patient 20 years old, female. Weight loss, intermittent diarrhea with rectal bleeding for 6 months, barium meal imaging diagnosis of Crohn’s disease, colon biopsy confirmed Crohn’s disease granuloma. With prednisolone 40mg / day, due to serious mental illness and forced withdrawal. The next year, although with sulfasalazine 2-3g / day, Crohn’s disease is still developing. Weight loss, ankle swelling, hypoproteinemia, menopause. Then switch to oral Cyclosporin 16mg / kg / day and 8mg / kg / day. During this period no other treatment. After eight weeks of treatment, the patient’s general condition improved, abdominal pain disappeared, stool was normal, ankle edema disappeared, menstrual disorders improved. ESR decreased from 45 to 28mm / hr, continued to rise