在牙菌斑生物膜中,有超过700种的微生物已经被鉴别出来[1],细胞密度可以达到1011CFU/m l[2]。牙菌斑生物膜中微生物的高密度和多样性,加上有限的能量供应,导致了种间的激烈竞争和相互协同。生物膜中的各种微生物,在通常情况下保持着一种相互平衡的状态,可以抵抗外来病原体的入 In the plaque biofilm, more than 700 species of microorganisms have been identified [1], cell density can reach 1011CFU / ml [2]. The high density and diversity of microorganisms in plaque biofilms, coupled with limited energy supply, have led to intense competition and synergies between species. The various microorganisms in the biofilm normally maintain a state of equilibrium with each other and resist the ingress of foreign pathogens