目的:了解某院抗菌药物的使用状况及细菌耐药率的变化趋势,为临床合理使用抗菌药物提供依据。方法:利用用药频度(DDDs)分析方法计算出DDDs/平均每床日值,对某院2005-2009年抗菌药物消耗量进行计算,并对同期病原菌培养分离结果和药敏试验中各类抗菌药物的耐药率进行分析,针对用药不合理现象探讨临床用药对策。结果:药品的使用频度与细菌耐药率具有一定的相关性。结论:抗感染治疗应结合临床合理地选用抗菌药物,防止和减缓细菌耐药性产生。 Objective: To understand the usage status of antimicrobials in a hospital and the change tendency of drug resistance rate of bacteria in a hospital, so as to provide basis for the rational use of antimicrobial agents in clinic. Methods: The daily DDDs / average bed daily value (DDDs) was calculated by DDD analysis. The antimicrobial consumption of a hospital from 2005 to 2009 was calculated. The antimicrobial activity Drug resistance rate of analysis, in view of irrational drug use to explore clinical drug countermeasures. Results: The frequency of drug use and bacterial resistance rate has a certain correlation. Conclusion: Anti-infective therapy should be combined with clinical and rational use of antimicrobial agents to prevent and slow down the emergence of bacterial resistance.