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细胞色素P450 1A1(CYP 1A1)与癌症的关系十分密切,许多化学致癌物均需经CYP 1A1代谢活化后才能发挥其致癌作用。槲皮素(Quercetin,Que)具有抗炎、抗过敏、抗肿瘤等多种生物活性及药理作用。啮齿类动物实验显示槲皮素能抑制致癌剂、促癌剂的致癌、促癌作用。但由于人肝标本的缺乏,故以往对槲皮素的抗癌作用研究主要集中在细胞或动物实验上。我们对人肝L-02细胞和人肝组织的9-乙氧基-3-异吩噁唑酮-0-
The relationship between cytochrome P450 1A1 (CYP 1A1) and cancer is very close. Many chemical carcinogens require the metabolic activation of CYP 1A1 to exert their carcinogenic effects. Quercetin (Que) has anti-inflammatory, anti-allergic, anti-tumor and other biological activities and pharmacological effects. Rodent experiments have shown that quercetin can inhibit the carcinogenic and cancer-promoting effects of carcinogens and carcinogens. However, due to the lack of human liver specimens, previous studies on the anti-cancer effects of quercetin have focused on cell or animal experiments. Our 9-ethoxy-3-isoxazolone- 0-for human liver L-02 cells and human liver tissue