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在发展中国家,婴儿猝死综台征(SIDS)是1岁以内婴儿死亡的主要原因。其发生率与呼吸道感染相关,特别与毛细支气管的入院率相关。大约40～75%的患者在死前一周有轻度上呼吸道各种病毒感染的证据。因此,对一种常见病毒病原体的特异性应答在流行病学上是可能的。所以,分析肺免疫学状态可能有助于回答SIDS 是否发生免疫学调节障碍。作者在南澳大利亚收集了16例既往健康突然和意外死亡婴儿(假定为SIDS,平均3.8个月龄,范围1～7个月)的肺灌洗标本和肺组织。用同样的方法,从8例对照者(平均4.8个月龄,范围2～10个月)收集了肺灌洗标本,从4例对照者(平均5.3月龄,
In developing countries, sudden infant death syndrome (SIDS) is the leading cause of death among infants under one year of age. Its incidence is associated with respiratory infections, particularly associated with admission to the bronchioles. Approximately 40-75% of patients have evidence of a mild viral infection of the upper respiratory tract one week prior to their death. Therefore, a specific response to a common viral pathogen is epidemiologically possible. Therefore, analyzing the status of lung immunology may help to answer SIDS whether there is an immunological regulatory disorder. The authors collected lung lavage specimens and lung tissue from 16 previously un- dercoming sudden and accidental death of healthy infants (assumed to be SIDS, mean 3.8 months of age, range 1 to 7 months) in South Australia. In the same way, lung lavage samples from 8 controls (mean 4.8 months of age, range 2 to 10 months) were collected from 4 control subjects (mean 5.3 months,