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目的观察糖尿病微血管病变患者的糖化血红蛋白情况及其血液流变学的关系。方法应用全自动血细胞分析仪和生化分析仪,测定78例糖尿病患者(其中有微血管病变者42例,无微血管病变者36例)及40名健康对照者的糖化血红蛋白、血小板平均体积(MPV)、血小板分布宽度(PDW)、血小板计数(PLT),分析它们在正常人和糖尿病患者不同时期的变化。结果糖尿病患者的糖化血红蛋白、血小板平均体积、血小板分布宽度明显高于健康对照组(P<0.01),有微血管病变者明显高于无微血管病变者(P<0.01),正常人和糖尿病患者的血小板计数无显著变化(P>0.05)。结论糖化血红蛋白、血小板平均体积、血小板分布宽度联合检测对糖尿病患者微血管病变的诊断具有重要价值。
Objective To investigate the relationship between hemoglobin A1c (HbA1c) and hemorheology in patients with diabetic microangiopathy. Methods Using automatic hematology analyzer and biochemical analyzer, the hemoglobin A1c, platelet mean volume (MPV), hemoglobin A1c (HbA1c) in 78 patients with diabetes mellitus (including 42 patients with microvascular disease, 36 patients without microvascular disease) and 40 healthy controls were measured. Platelet distribution width (PDW), platelet count (PLT), and analyze their changes in different periods of normal and diabetic patients. Results The width of glycosylated hemoglobin, the average platelet volume and the distribution of platelets in diabetic patients were significantly higher than those in healthy controls (P <0.01), those with microvascular disease were significantly higher than those without microvascular disease (P <0.01), and those in normal subjects and diabetic patients No significant change in count (P> 0.05). Conclusions The combined detection of HbA1c, platelet mean volume and platelet distribution width is of great value in the diagnosis of diabetic microangiopathy.