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对４４例原发性单纯型肾病综合征患儿及２８例相应性别、年龄的健康儿童的过敏史、血清免疫球蛋白Ｅ类（ＩｇＥ）及Ｔ辅助细胞分泌的白细胞介素４（ＩＬ一４）进行研究。发现：患儿既往和家族过敏史均高于健康儿童；ＩｇＥ和ＩＬ一４在极期均明显增高，且两者呈显著性直线正相关；ＩＬ一４与２４小时尿蛋白也呈显著性正相关。提示：Ｔ辅助细胞活化后分泌的高水平ＩＬ一４可能是ＩｇＥ增高的原因；ＩＬ一４有可能参与了导致蛋白尿的病理过程，但尚须进一步证明。
The allergic history, serum immunoglobulin E (IgE) and interleukin-4 (IL-4) secreted by T helper cells in 44 children with primary nephrotic syndrome and 28 healthy children of corresponding age and gender were analyzed. )research. The results showed that both past and family history of allergy in children were higher than those in healthy children. The levels of IgE and IL-4 were significantly increased in the polar phase, and both were significantly positive linear correlation. The levels of IL-4 and 24-hour urinary protein were also significantly positive Related. It is suggested that the high level of IL-4 secreted by T-helper cells may be responsible for the increased IgE. IL-4 may be involved in the pathological process leading to proteinuria, but further evidence is needed.