【摘 要】
：
目的:观察N-甲基-N-亚硝脲(N-methyl-N-nitrosourea,MNU)对SD大鼠视网膜光感受器细胞的毒性作用.方法:雌性SD大鼠100只,分17组,正常对照组4只,其余组各6只.在大鼠生后50 d,分
【机 构】
：
中山大学中山眼科中心,新乡医学院药学院
【基金项目】
：
国家自然科学基金;广东省科技厅科技计划
论文部分内容阅读
目的:观察N-甲基-N-亚硝脲(N-methyl-N-nitrosourea,MNU)对SD大鼠视网膜光感受器细胞的毒性作用.方法:雌性SD大鼠100只,分17组,正常对照组4只,其余组各6只.在大鼠生后50 d,分别一次腹腔注射MNU 50mg/kg、60mg/kg、70mg/kg和80mg/kg.在MNU处理后24、48、72 h和7 d处死大鼠,取眼球,做组织学检查.结果:不同剂量的MNU均引起中心视网膜和周边视网膜损伤,其损害的程度与MNU的剂量呈正比.作用24 h后,可见视网膜光感受器细胞核固缩、破坏及光感受器外节部定向紊乱;48 h或72 h后,可见光感受器细胞丧失;7 d后,外颗粒层和光感受层几乎完全消失.结论:MNU对大鼠视网膜光感受器细胞有选择性的毒性作用,该作用呈剂量和时间依赖性.
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