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眼部丝虫病的发生主要起因于宿主对死的或将要死的盘尾丝虫的炎症反应。在角膜,这种反应表现为新血管的生成和角膜浑浊化。动物模型研究表明,丝虫性角膜炎,出现嗜中性粒细胞和嗜酸性粒细胞通过新形成的血管网络向角膜移动的现象。但该病理过程的根本原因,即丝虫诱导角膜血管生成的机制并不清楚。本文作者对盘尾丝虫激活相关分泌蛋白(Ov-ASP)在此过程中的作用进行了探讨。
Ocular filariasis occurs mainly due to the host’s inflammatory response to dead or dying onchiasis. In the cornea, this reaction manifests as neovascularization and corneal opacification. Animal model studies have shown that in filagrotal keratitis there is a shift of neutrophils and eosinophils to the cornea through a newly formed network of blood vessels. However, the root cause of this pathological process, that is, the mechanism by which filarial worms induce corneal angiogenesis, is not clear. The author of this paper on the onchocercia activated secreted protein (Ov-ASP) in the process of the role were discussed.