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目的 :探讨环磷酰胺 (CP)对昆明种小白鼠精子畸形的影响。方法 :取小白鼠随机分成阴性对照组 ,CP组 (分低、中、高剂量组 ) ,经口灌胃 ,连灌 5d ,药后 30天处死动物取两侧附睾液涂片 ,观察小白鼠精子畸形的影响。结果 :CP2 0mg kg剂量组可引起精子畸形数量增加 ,且随着剂量加大 ,畸形精子数也随之增加 ,与阴性对照组比较 ,差异具有非常显著性意义(P <0 0 1) ;各剂量组之间进行比较 ,差异均同样具有显著性意义。结论 :CP可引起小白鼠生殖细胞的毒作用 ,诱导雄性小白鼠精子畸形数量增加
Objective: To investigate the effect of cyclophosphamide (CP) on sperm deformity in Kunming mice. Methods: The mice were randomly divided into a negative control group, CP group (low, middle and high dose group), orally administered by mouth and continuous irrigation for 5 days. The animals were sacrificed on the 30th day after operation to take epididymal smear. Effects of sperm deformity. Results: CP2 0mg kg dose group can cause an increase in the number of sperm deformity, and as the dose increased, the number of abnormal sperm also increased, compared with the negative control group, the difference was significant (P <0.01); Dose groups were compared, the differences are equally significant. Conclusion: CP can cause germ cell toxicity in mice and induce the increase of sperm deformity in male mice