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目的 :探讨血管紧张素转换酶 (ACE)基因的缺失多态性与妊高征的关系。方法 :对 5 2例妊高征患者 (观察组 )及 10 0例正常产妇 ,应用聚合酶链反应技术检测 ACE基因的缺失 /插入多态性。结果 :观察组的缺失型纯合子 (DD型 ) ACE基因占 6 5 % ,高于对照组的 16 % ;观察组的缺失型 (D型 ) ACE等位基因出现频率为 75 % ,亦高于对照组的 33% (P<0 .0 1)。结论 :妊高征的发病与 ACE基因的缺失多态性有关
Objective: To investigate the relationship between angiotensin converting enzyme (ACE) deletion polymorphism and pregnancy induced hypertension. Methods: The deletion / insertion polymorphism of ACE gene was detected by polymerase chain reaction (PCR) in 52 cases of PIH (observation group) and 100 normal pregnant women. Results: The ACE gene deletion type homozygote (DD) in the observation group accounted for 65% of the control group, which was 16% higher than that in the control group. The frequency of ACE deletion in the observation group was 75% Control group, 33% (P <0.01). Conclusion: The incidence of PIH is related to the deletion polymorphism of ACE gene