Ⅻ因子(Hageman Factors,HF因子)是1953年Ratnoff研究Hageman的血液时意外发现的。至今世界上已有200余例遗传性Ⅻ因子缺乏症报导。近10年来,Ⅻ是研究相当广泛的一个凝血因子,它与凝血、纤溶、激肽和补体等四个系统相关。本文就有关Ⅻ的一些研究进展作一综述。Ⅻ的接触激活与分子结构人的Ⅻ为一种血浆单链糖蛋白,分子量(MW)8万。放射免疫测定血浆含量为29ug/ml。当Ⅻ与“异物表面”接触时,Ⅻ被吸附 Hageman Factors (HF) were unexpectedly discovered by Ratnoff in 1953 when Hageman’s blood was studied. To date, more than 200 cases of hereditary Ⅻ factor deficiency have been reported in the world. In the past 10 years, Ⅻ is a quite extensive study of a clotting factor, which is associated with four systems of coagulation, fibrinolysis, kinins and complement. This article summarizes some of the research advances in this article.接 contact activation and molecular structure Human Ⅻ is a plasma single-chain glycoprotein with a molecular weight (MW) of 80,000. Radioimmunoassay plasma concentration of 29ug / ml. When Ⅻ and “foreign body surface” contact, Ⅻ is adsorbed