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结核病目前仍是感染性疾病中的最大杀手,每年导致300万人丧生,其中最主要原因是结核分枝杆菌耐药株的出现和传播及其难治性。现将近几年有关报道整理,探讨其难治原因,提出临床上一些对策。 1 难治性因素 1.1 临床因素:造成肺结核难治的临床因索较为复杂,不坚持规则用药或全程用药是失败的最主要原因。叶志忠等分析了27例耐多药结核病(MDR-TB)原因,不规则18/27例占67％,初始耐药4/27例占15％,医务人员处理不当5/27例占18％。万传贵统计了108例难治性肺结核,其中有28例曾中断治疗达83次,比例高达5.48％.中断治
Tuberculosis is still the biggest killer in infectious diseases and causes 3 million deaths each year. The most important reason is the emergence and spread of drug-resistant strains of Mycobacterium tuberculosis and its refractory nature. Now in recent years, the report finishing, to explore the reasons for its refractory to put forward some clinical countermeasures. 1 refractory factors 1.1 clinical factors: the clinical causes of tuberculosis refractory more complex, do not adhere to the rules of the drug or medication is the main reason for the failure. Ye Zhizhong analyzed 27 cases of multidrug-resistant tuberculosis (MDR-TB) causes, irregular 18/27 cases accounted for 67%, initial resistance 4/27 cases accounted for 15%, medical staff improper handling 5/27 cases accounted for 18%. Wan Chuan-you statistics 108 cases of refractory tuberculosis, of which 28 cases had interrupted treatment up to 83 times, the proportion of up to 5.48%. Interrupted treatment