应用细胞核仁组成区嗜银蛋白（ＡｇＮＯＲｓ）染色技术，对８２例口腔粘膜良恶性病变进行研究。结果表明，口腔粘膜恶性病变ＡｇＮＯＲｓ团块形态不规则，分布离散；ＡｇＮＯＲｓ计数明显高于正常口腔粘膜和良性病变组，但不同组织类型和分级的恶性病变ＡｇＮＯＲｓ计数无显著差异，与其生物学行为相一致。由此可见，ＡｇＮＯＲｓ形态观察和定量研究有助于口腔粘膜良恶性病变的鉴别和癌前病变的早期诊断，但对不同组织类型恶性病变的区分和分级无意义 82 cases of oral mucosa benign and malignant lesions were studied using AgNORs staining technique. The results showed that the morphology of AgNORs in oral mucosal malignant lesions was irregular and distributed. The AgNORs counts were significantly higher than those in normal oral mucosa and benign lesions, but there was no significant difference in the AgNORs count between malignant lesions of different histological types and grading , Consistent with their biological behavior. Thus, morphological observation and quantitative study of AgNORs is helpful for the differential diagnosis of benign and malignant oral mucosa lesions and early diagnosis of precancerous lesions, but it is not meaningful to differentiate and classify malignant lesions of different tissue types