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为了探讨影响糖代谢异常者尿微量白蛋白的因素 ,选取 1 994年口服葡萄糖耐量试验 (OGTT)筛查时 ,糖代谢异常但尿白蛋白排泄率 (UAER) <2 0 μg/min的患者共 5 41例 ,5年后复查 1 994年曾经检测过的所有项目 ;排除急性感染及其他肾脏疾病、冠心病心绞痛、心肌梗死、心功能不全、脑卒中患者。结果 :1 ) 5年后UAER≥ 2 0 μg/min组共1 1 3例 ,发生率为 2 0 .9% ,其中糖尿病占 61 .9% ,空腹血糖受损 (IFG)和糖耐量减低 (IGT)分别为 1 3 .3 %、1 7.7% ,IFG、IGT同时存在的占 7.1 % ;2 )UAER≥ 2 0 μg/min组 ,高血压病程、血压、BMI、血糖、血脂、空腹胰岛素水平均显著高于UAER正常组 (n =42 8) (P =0 .0 0 0～ 0 .0 3 3 ) ;3 )UAER≥ 2 0 μg/min组 ,5年后各项临床指标与基线值比较 ,高血压病程、血压、吸烟量较前有显著增高 (P =0 .0 0 1～ 0 .0 45 ) ;多元逐步回归分析显示 ,UAER与收缩压、OGTT 2h血糖呈显著正相关 ,P分别为 0 .0 0 0和 0 .0 1 4。提示 :异常的尿白蛋白排泄率与高血压、高血糖明显相关 ,提出及早控制血压、血糖对预防尿白蛋白排泄率增加同等重要
In order to investigate the factors affecting the microalbuminuria in patients with abnormal glucose metabolism, we selected patients with abnormal glucose metabolism but urinary albumin excretion rate (UAER) <20 μg / min during the oral glucose tolerance test (OGTT) test in 1994, 5 41 cases. After 5 years, all items that had been tested in 1994 were reviewed. Acute infections and other kidney diseases, angina pectoris, myocardial infarction, cardiac insufficiency and stroke patients were excluded. Results: 1) A total of 113 cases with a UAER ≥ 20 μg / min after 5 years were found with a incidence of 20.9%, of which diabetes was 61.9%, impaired fasting glucose (IFG) and impaired glucose tolerance IGT) were 13.3% and 17.7% respectively, while IFG and IGT accounted for 7.1% at the same time. 2) UAER≥20 μg / min, duration of hypertension, blood pressure, BMI, blood glucose, serum lipids, fasting insulin Were significantly higher than those in the normal UAER group (n = 42 8) (P = 0.0000-0.33); 3) After 5 years, the clinical parameters of the UAER≥20 μg / Compared with the former, the course of hypertension, blood pressure and smoking were significantly increased (P = 0.001 ~ 0.455). Multiple stepwise regression analysis showed that there was a significant positive correlation between UAER and systolic blood pressure and OGTT 2h blood glucose, P 0 0 0 0 and 0. 0 1 4, respectively. Tip: abnormal urinary albumin excretion rate was significantly associated with hypertension and hyperglycemia, proposed early control of blood pressure, blood glucose to prevent urinary albumin excretion rate increase is equally important