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疟原虫从裂殖子发育成红内期滋养体首先是吸附在红细胞的表面。由于很难分离得到纯的具有活性的裂殖子,所以对于吸附过程中的生化特征了解甚少。Miller等认为,各种红细胞表面存在着识别疟原虫的特异受体,并认为恶性疟原虫的侵入与红细胞表面的糖蛋白有关。Sherman的实验还表明裂殖子不再侵犯经胰蛋白酶、糜蛋白酶或唾液酸苷酶处理过的红细胞。本实验目的在于进一步了解裂殖子侵犯人红细胞时红细胞膜蛋白所起的作用。
Plasmodium develops from merozoite to red mid-trophozoite first adsorbed on the surface of red blood cells. Due to the difficulty of isolating purely active merozoites, little is known about the biochemical characteristics of the adsorption process. Miller, etc., that there is a variety of red blood cell surface recognition of Plasmodium-specific receptors, and that the invasion of Plasmodium falciparum erythrocyte surface glycoprotein. Sherman’s experiment also showed that merozoites no longer violate erythrocytes that have been treated with trypsin, chymotrypsin or neuraminidase. The purpose of this experiment is to further understand the role played by erythrocyte membrane proteins when merozoites invade human erythrocytes.