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本文对健康雄性SD大鼠进行亚慢性染毒,经腹腔注射CCl_4、P_4和TNT。发现染毒三周后,CCl_4组发生明显的肝纤维化并伴有肝组织脂变、水样变及明显的点块状坏死。P_4和TNT染毒十二周后才可见肝窦隙、汇管区有胶原纤维增生,并伴有脂变和灶状坏死,在此以前以脂变为主。
In this paper, healthy male Sprague - Dawley rats were subchronicly exposed to intraperitoneal injection of CCl 4, P 4 and TNT. After three weeks of exposure, significant hepatic fibrosis and hepatic steatosis, watery changes and obvious massive necrosis were observed in CCl_4 group. P_4 and TNT were seen only after twelve weeks of hepatic sinusoidal gap, portal area collagen fibers hyperplasia, accompanied by lipid and focal necrosis, prior to lipid-based.