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目的:测量乙型肝炎不同疾病状态下患者的生命质量效用权重。方法:随机选取北京市地坛医院4种疾病状态下的乙肝患者各60例,采用EQ5D问卷对患者进行问卷调查,并收集患者的性别和年龄。基于日本的人群偏好积分体系,利用多元广义线性模型评估各状态下患者的生命质量效用权重。结果:在校正了年龄和性别因素后,乙肝4个状态下患者的生命质量效用权重值为:慢性乙肝患者的生命质量效用权重值为0.818±0.038,代偿期肝硬化患者的生命质量效用权重值为0.802±0.033,失代偿期肝硬化患者的生命质量效用权重值为0.632±0.053,肝细胞癌患者的生命质量效用权重值为0.406±0.066。结论:患者患病程度越严重,患者的生命质量越差,生命质量效用权重越低。
PURPOSE: To measure the quality of life weight utility of patients under different disease states of Hepatitis B. Methods Sixty patients with hepatitis B were randomly selected from Ditan Hospital of Beijing Municipality in four kinds of disease states. Questionnaire was conducted by EQ5D questionnaire and the gender and age of the patients were collected. Based on the Japanese population preference points system, the multivariate generalized linear model was used to assess the patients’ quality of life utility weights in each state. Results: After adjusting for age and gender, the quality of life weight utility values of patients with hepatitis B were 0.818 ± 0.038, and those of patients with decompensated cirrhosis were The value of 0.802 ± 0.033, the quality of life weight of patients with decompensated cirrhosis was 0.632 ± 0.053, and the weight of life quality of patients with hepatocellular carcinoma was 0.406 ± 0.066. Conclusion: The more severe the patient’s illness, the worse the quality of life of patients and the lower the weight of life quality.