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为探讨牛磺酸对脑缺血疾患的治疗机制,在大鼠脑I/R模型和脑血栓病人临床观察牛磺酸治疗效果中,发现牛磺酸显著减轻脑组织损伤,抑制血浆和脑脊液内皮素水平增加和血小板聚集,提示牛磺酸抑制内皮素释放可能是其防治脑缺血损伤的机制之一.
In order to explore the therapeutic mechanism of taurine on cerebral ischemic disorders, taurine was found to significantly reduce brain damage and inhibit the plasma and cerebrospinal fluid endothelium in the rat brain I / R model and clinical observation of taurine in patients with cerebral thrombosis Elevated levels of insulin and platelet aggregation, suggesting that taurine inhibition of endothelin release may be one of the mechanisms of prevention and treatment of cerebral ischemia.