AIM:The current study was to determine the serum/pLasmalevels of VEGF,IL-6,malondialdehyde (MDA),nitric oxide(NO),PCT and CRP in gastric carcinoma and correlation withthe stages of the disease and accompanying infection.METHODS:We examined the levels of serum VEGF,IL-6,PCT,CRP and plasma MDA,NO in 42 preoperative gastriccancer patients and 23 healthy subjects.There were infectionanamneses that had no definite origin in 19 cancer patients.RESULTS:The VEGF levels (mean±SD; pg/mL) were478.05±178.29 and 473.85±131.24 in gastric cancer patientswith and without infection,respectively,and these valueswere not significantly different (P>0.05).The levels of VEGF,CRP,PCT,It-6,MDA and NO in cancer patients weresignificantly higher than those in healthy controls and thelevels of CRP,PCT,It-6,MDA and NO were statisticallyincreased in infection group when compared with non-infection group (P<0.001).CONCLUSION:Although serum VEGF concentrations wereincreased in gastric cancer,this increase might not be relatedto infection.CRP,PCT,IL-6,MDA and NO have obviousdrawbacks in the diagnosis of infections in cancer patients.These markers may not help to identify infections in theprimary evaluation of cancer patients and hence to avoidunnecessary antibiotic treatments as well as hospitalization.According to the results of this study,IL-6,MDA,NO andespecially VEGF can be used as useful parameters todiagnose and grade gastric cancer. AIM: The current study was to determine the serum / pLasmalevels of VEGF, IL-6, malondialdehyde (MDA), nitric oxide (NO), PCT and CRP in gastric carcinoma and correlation with the stages of the disease and accompanying infection. METHODS: We examined the levels of serum VEGF, IL-6, PCT, CRP and plasma MDA, NO in 42 preoperative gastriccancer patients and 23 healthy subjects. Everyone was infectedanamneses that had no definite origin in 19 cancer patients .RESULTS: The VEGF levels (mean ± SD; pg / mL) were 478.05 ± 178.29 and 473.85 ± 131.24 in gastric cancer patients with and without infection, respectively, and these valueswere not significantly different (P> 0.05) .The levels of VEGF, CRP, PCT, MDA and NO in cancer patients weresignificantly higher than those in healthy controls and the levels of CRP, PCT, It-6, MDA and NO were statistically found in infection group when compared with non-infection group (P <0.001) .CONCLUSION: Although serum VEGF Confirmation of increments in gastric cancer, this increase might n ot be relatedto infection. CRP, PCT, IL-6, MDA and NO have obviouslydrawbacks in the diagnosis of infections in cancer patients .sentials markers may not help to identify infections in theprimary evaluation of cancer patients and hence to avoidunnecessary antibiotic treatments as well as hospitalization. According to the results of this study, IL-6, MDA, NO andespecially VEGF can be used as useful parameters for todiagnose and grade gastric cancer.