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目的探讨肌钙蛋白I(cTnI)、肌红蛋白(Mb)浓度与急性心肌梗死(AMI)合并左心衰的关系。为左心衰患者的临床诊断提供依据。方法AMI无合并心力衰竭组171例,于胸痛发作后3h抽静脉血3mL送检。AMI合并左心衰组127例,于胸痛发作后3h表现为有左心衰症状时抽静脉血3mL。采用全自动微粒子化学发光分析仪定量检测cTnI、Mb。结果AMI无合并心衰组cTnI的浓度为(16.71±14.19)μg/L,Mb的浓度为(522.22±392.22)μg/L。AMI患者cTnI于胸痛3h后随时间增加而逐步增高,有左心衰症状时cTnI的浓度为(29.08±21.97)μg/L,Mb的浓度为(1010.96±935.98)μg/L,两组比较有统计学意义(P<0.05)。结论AMI患者cTnI浓度与心肌梗死部位及面积大少有关,cTnI浓度的测定对AMI合并左心衰的诊治有较大意义。
Objective To investigate the relationship between cTnI, Mb and AMI with left heart failure. Provide the basis for the clinical diagnosis of patients with left heart failure. Methods 171 patients with AMI without heart failure group were treated with 3 mL venous blood 3h after the onset of chest pain. AMI with left heart failure group of 127 cases, 3h after the onset of chest pain in the presence of left ventricular dysfunction, venous pumping 3mL. Quantitative detection of cTnI, Mb using automated particle chemiluminescence analyzer. Results The concentration of cTnI in AMI patients without heart failure was (16.71 ± 14.19) μg / L and Mb was (522.22 ± 392.22) μg / L. The level of cTnI in AMI patients was 29.08 ± 21.97 μg / L and that of Mb was (1010.96 ± 935.98) μg / L in patients with AMI after 3 hours of chest pain. The levels of cTnI in AMI patients were (1010.96 ± 935.98) μg / L, Statistical significance (P <0.05). Conclusions The concentration of cTnI in AMI patients is related to the location and area of myocardial infarction. The determination of cTnI concentration has great significance for the diagnosis and treatment of AMI complicated with left heart failure.