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目的 :观察胞磷胆碱加小剂量奋乃静治疗脑血管疾病所致精神障碍的疗效。方法 :脑血管疾病所致精神障碍病人 4 6例 ,随机分为对照组 2 2例 ,用奋乃静 3～ 5mg ,po ,bid ,疗程 6wk ;治疗组 2 4例 ,用奋乃静 3～ 5mg ,po ,bid ,疗程 6wk ,同时合并用胞磷胆碱 2 50～ 50 0mg加入 5%葡萄糖注射液50 0mL ,iv ,drip ,qd ,疗程 10d。结果 :治疗wk 2末治疗组BPRS总分显著下降 ,P <0 .0 1,57%的病人起效时间为 7～ 14d ,2 6%病人为 <7d ,总有效率为 75% ;对照组分别为 2 0 %和 0 ,总有效率 4 1%。治疗组不良反应轻微。结论 :胞磷胆碱加小剂量奋乃静治疗脑血管疾病所致精神障碍起效时间早、精神症状缓解快、安全、疗效优于单用奋乃静。
Objective: To observe the effect of citicoline plus a small dose of perphenazine on mental disorders caused by cerebrovascular diseases. Methods: Forty-six patients with mental disorders caused by cerebrovascular disease were randomly divided into control group (22 cases), perphenazine (3-5 mg), po, bid for 6 weeks. Treatment group (24 cases) 5mg, po, bid, course of treatment 6wk, combined with citicoline 50 ~ 50 0mg 5% glucose injection 50 0mL, iv, drip, qd, treatment 10d. Results: The total score of BPRS decreased significantly in the treatment group of wk 2, P <0. 0, The onset time of the patients with 57% was 7 ~ 14d, that of 26% of the patients was <7d, the total effective rate was 75% Respectively 20% and 0, the total efficiency of 4 1%. Adverse reactions in the treatment group were mild. CONCLUSION: Citicoline combined with low-dose perphenazine can treat mental disorders caused by cerebrovascular disease with early onset, rapid relief of mental symptoms, safety and efficacy over perphenazine alone.