时辰药理学与临床应用５５０００３贵州省贵阳监狱医院李建华药物进入体内发生效应，取决于药物的吸收与分布和代谢情况。影响药物吸收和分布除了药物的理化性质，首过效应和吸收环境；血浆蛋白的结合能力；局部器官的血流量；细胞膜屏障（血脑屏障、胎盘屏障）；体液ＰＨ... Time pharmacology and clinical application 550003 Li Jianhua, Guiyang Prison Hospital, Guizhou Province Drugs enter the body occurs, depending on the absorption and distribution of drugs and metabolism. Affect the absorption and distribution of drugs in addition to the physical and chemical properties of the drug, the first pass effect and the absorption of the environment; plasma protein binding capacity; local organ blood flow; cell membrane barrier (BBB, placental barrier);