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目的:探讨老年2型糖尿病(T2DM)患者正常范围内血浆纤维蛋白原(FIB)与糖尿病病程的相关性。方法:回顾性分析，收集2016年1月至2019年10月同济大学附属天佑医院收治的1 116例老年T2DM患者的临床资料和生化指标。将糖尿病病程按四分位数分为Q1组(<2.0年)276例、Q2组(2.0～7.9年)278例、Q3组(8.0～13.9年)280例、Q4组(≥14.0年)282例，分析FIB与糖尿病病程的相关性。结果:随着糖尿病病程的延长，FIB水平升高(n P<0.05)。Pearson相关分析结果显示，糖尿病病程与FIB、年龄和血肌酐呈正相关(均n P<0.01)，且均与性别无关。多元逐步回归分析显示，病程是FIB独立影响因素(n β＝0.104，n P<0.01)。Logistic多元回归分析结果显示，在校正性别、年龄、体质指数、收缩压、舒张压、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血肌酐、丙氨酸氨基转移酶、空腹血糖、糖化血红蛋白、吸烟和饮酒因素后，Q4组患者发生高FIB血症的危险性是Q1组患者的2.436倍(95%n CI：1.317～4.507，n P<0.01)，Q3组患者发生高FIB血症的危险性是Q1组患者的2.104倍(95%n CI：1.144～3.871，n P<0.05)。以FIB 75分位值(3.70 g/L)为分界值，糖尿病病程与高FIB血症的受试者工作特征曲线(ROC)所得糖尿病病程的最佳切点值为9.5年。n 结论:老年T2DM患者血浆FIB水平与糖尿病病程呈正相关。“,”Objective:To investigate the relationship between normal plasma fibrinogen(FIB)levels and disease duration in elderly patients with type 2 diabetes mellitus(T2DM).Methods:Clinical data and biochemical test results of 1 116 elderly subjects with T2DM admitted to the Department of Endocrinology of Shanghai Tianyou Hospital from January 2016 to October 2019 were retrospectively collected and analyzed.Subjects were classified into four groups based on the duration of DM: the Q1 group(n=276, < 2.0 years), the Q2 group(n=278, 2.0-7.9 years), the Q3 group(n=280, 8.0-13.9 years)and the Q4 group(n=282, ≥ 14.0 years). The correlation between FIB and the duration of DM was analyzed.Results:With the prolongation of DM duration, FIB levels increased significantly(n P<0.05). Pearson correlation analysis showed that the duration of DM was positively correlated with FIB, age and serum creatinine(n P<0.01). Multiple stepwise regression analysis showed that the duration of DM was an independent factor for FIB(n β=0.104, n P<0.01). Logistic multiple regression analysis showed that after adjusting for sex, age, body mass index, systolic pressure, diastolic pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum creatinine, alanine aminotransferase, fasting plasma glucose, glycosylated hemoglobin, smoking and drinking, the risk of hyperfibrinogenemia was 2.436 and 2.104 times higher, respectively, in Group Q4 and Group Q3 than in Group Q1(95%n CI: 1.317-4.507, n P<0.01; 95%n CI: 1.144-3.871, n P<0.05). With the third-quartile FIB(3.70 g/L)as the cut-off value, the optimal cut-off point of the DM course was 9.5 years as calculated by receiver operating characteristic(ROC)curve analysis of DM duration and hyperfibrinogenemia.n Conclusions:The FIB level is positively correlated with DM duration in elderly patients with T2DM.