亚急性硬化性全脑炎(SSPE)一向被认为是由病毒所引起,就广义而言属慢病毒感染,狭义来讲与慢病毒感染的Creutzfeldt-Jakob病和Curu病不同,其发病和病毒持续感染的机理尚未搞清,本文概述了迄今有关其发生机理方面的各种论说。一、SSPE的概念 SSPE是从小儿期到青春期较少见的由麻疹病毒或其变异株在腩内持续感染的亚急性慢性脑炎。初期症状多以缓慢地出现性格变化和智力降低、进行性痴呆、肌肉阵挛性 Subacute sclerosing full encephalitis (SSPE) has always been considered to be caused by a virus, which is broadly defined as a lentivirus infection. In a narrow sense, Creutzfeldt-Jakob disease and Curu’s disease, which are lentivirus infections, differ in their incidence and duration The mechanism of infection has not yet been clarified, and the article outlines so far various theories about its mechanism of occurrence. First, the concept of SSPE SSPE is from childhood to adolescence less common in the belly by the measles virus or its mutant persistent infection in the subacute chronic encephalitis. Early symptoms and more slowly with personality changes and mental retardation, progressive dementia, myoclonic